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239000008194 pharmaceutical composition Substances 0.000 claims description 20. 238000006467 substitution reaction Methods 0.000 claims description 39. 239000002157 polynucleotide Substances 0.000 claims description 68. 229920000023 polynucleotide Polymers 0.000 claims description 68. 150000001413 amino acids Chemical group 0.000 claims description 93. 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims description 109. 230000014509 gene expression Effects 0.000 claims description 128. 108090000623 proteins and genes Proteins 0.000 claims description 137. 102000004169 proteins and genes Human genes 0.000 claims description 137. 102100009534 TNF Human genes 0.000 claims abstract description 57. 
108010042215 OX40 Ligand Proteins 0.000 claims abstract description 98. 229920001184 polypeptide Polymers 0.000 claims abstract description 307. 102000002627 4-1BB Ligand Human genes 0.000 claims abstract description 375. 125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 717. 239000003446 ligand Substances 0.000 title claims abstract description 696. 102000038129 antigens Human genes 0.000 title claims abstract description 759. 108091007172 antigens Proteins 0.000 title claims abstract description 759. 239000000427 antigen Substances 0.000 title claims abstract description 765. 230000027455 binding Effects 0.000 title claims abstract description 1424. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to EP14193260 priority Critical Priority to EP15183736 priority Priority to EP15188142 priority Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG Priority to PCT/EP2015/076528 priority patent/WO2016075278A1/en Application granted granted Critical Publication of ES2788979T3 publication Critical patent/ES2788979T3/en Status Active legal-status Critical Current Anticipated expiration legal-status Critical Links Original Assignee F Hoffmann La Roche AG Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Inventor Maria Amann Peter Bruenker Christina Claus Koller Claudia Ferrara Sandra Grau-Richards Christian Klein Viktor Levitsky Ekkehard Moessner Joerg Thomas Regula Pablo Umana Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number ES15797922T Other languages Spanish ( es) #TRUCAR CONTADOR LUZ DIGITAL 2015 PDF#
Wait for the conversion process to finish.Antigen-binding molecules comprising a ligand trimer of the TNF familyĭownload PDF Info Publication number ES2788979T3 ES2788979T3 ES15797922T ES15797922T ES2788979T3 ES 2788979 T3 ES2788979 T3 ES 2788979T3 ES 15797922 T ES15797922 T ES 15797922T ES 15797922 T ES15797922 T ES 15797922T ES 2788979 T3 ES2788979 T3 ES 2788979T3 Authority ES Spain Prior art keywords seq amino acid acid sequence antigen domain Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.
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